The study of culture—of the significance, meaning, and value of its various expressions and products—has traditionally been the domain of the humanities. With the elevation of culture to industry, and of creative institutions to the mainstay of economic activity and social arrangements in cities and across regions, it is time to ask whether the emergence of cultural industries generates a new humanities. What new modes of cultural comprehension and interdisciplinary tools of analysis are necessary to address the modes of conception, production, marketing and dissemination of cultural industries, their regional variety, the unequal cultural exchange across the globe and their reduction to consumer products, their impacts on cities and societies, and the working conditions facing those in the creative sector? What professional possibilities and responsibilities today face the humanities in engaging these recent developments? And what are the likely impacts on the humanities yet to come?