This is a famous line, and fully alert to the fact that BF was a genius, I feel this quotation would have been even more famous if he had said “…death and taxes and change”. Salient to this is the fact that in 1789 the French revolution was underway so change was a big topic of conversation.
In 2017 the social and workforce impacts resulting from the convergence of robotics, artificial intelligence and the Internet are much in focus. Change is happening quickly and deeply. As a consequence it is fair to suggest that the working lives of people born in 2000 will be profoundly different from people born only 30 years earlier.